Gallstones form when substances in bile (such as cholesterol or bilirubin) become imbalanced and crystallize, creating solid particles in the gallbladder. There are two main types of gallstones: cholesterol and pigment stones — most common being cholesterol stones, which are not directly linked to abnormal lipid profiles.
1. Excess cholesterol in bile:
If the liver secretes more cholesterol than bile can dissolve, excess cholesterol can form crystals and eventually stones.
2. Excess bilirubin:
Conditions like liver cirrhosis, biliary tract infections, or hemolytic anemia can cause the liver to produce too much bilirubin.
3. Incomplete emptying of the gallbladder:
If the gallbladder doesn't empty completely or often enough, bile becomes concentrated and stones can form.
Risk Factors: Obesity, rapid weight loss, pregnancy, gender (more common in women), age, diabetes, cirrhosis, and certain blood disorders.
Before deciding on surgery, a careful medical history and assessment is important to rule out concomitant diseases and ensure safe surgical outcomes.